DISCOVERIES

KOUMBALONES A and B

Source Plant

Found in Maprounea africana Muell.- Arg (Euphorbiaceae) originally collected in Park Manovo-Gounda-St. Floris in the vicinity of Camp Koumbala in May of 1987 (Fay 8002).

Chemical Structure

 Koumbalone A

 Koumbalone B 

Activity

The koumbalones were isolated from an organic extract that exhibited activity in the NCI's primary anti-HIV screen.

Reference

Kashman, Y., M.W. Bernart, M. Tischler, J.H. Cardellina II, and M.R. Boyd. 1993. Koumbalones A and B, new casbane diterpenes from Maprounea africana. J. Nat.
Prod. 57:426-430.

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