DISCOVERIES

BERSHACOLONE

Source Plant

Bershacolone is found in the roots of Maprounea africana Muell.-Arg. (Euphorbiaceae) originally collected in Park Manovo-Gounda-St. Floris in the vicinity of Camp Koumbala in May of 1987 (Fay 8002).

Chemical Structure

 Bershacolone

Activity

Bershacolone is a novel diterpene purified from an organic extract that exhibited activity in the NCI's primary anti-HIV screen.

Reference

Bernart, M.W., Y. Kashman, M. Tischler, J.H. Cardellina II, and M.R. Boyd. 1993. Bershacolone, an unprecedented diterpene cyclobutene from Maprounea africana. Tetrahedron Lett. 34:4461-4464.

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