DISCOVERIES

ENT-4'-O-METHYLGALLOCATECHIN

Source Plant

Ent-4'-O-methylgallocatechin was isolated from Panda oleosa Pierre (Pandaceae) originally collected in Gabon in the Lopé Reserve, south of Ayem in March of 1989 (McPherson 13783).

Chemical Structure

 Ent-4'-O-methylgallocatechin 

Activity

Ent-4'-O-methylgallocatechin was isolated in an organic extract of stem bark that exhibited HIV-inhibitory activity in the NCI's anti-HIV primary screen. The anti-HIV activity was produced by tannins, rather than the compound isolated. The compound was previously known from Cassia trachypus.

Reference

Bokesch, H.R., T.C. McKee, J.H. Cardellina II, and M.R. Boyd. 1994. Ent-4'-O-methylgallocatechin from Panda oleosa. Nat. Prod. Lett. 4:155-157.

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