DISCOVERIES

GALLOTANNINS

Source Plant

Anti-HIV galloylquinic acids were isolated from Lepidobotrys staudtii Engl. that was originally collected between Ekombe and Bekondo in the Southwest Province of Cameroon in January of 1987 (Etuge & Thomas 478).

Chemical Structure

 Gallotannin A

 Gallotannin B 

Activity

1,3,4,5-tetra-O-galloylquinic acid protected target cells from the cytophathic effects of HIV-1 and HIV-2 and also exhibited potent inhibition of cellular DNA polymerases, as well as of the reverse transcriptases of HIV-1 and HIV-2.

Reference

Bokesch, H.R., T.C. McKee, M.J. Currens, R.J. Gulakowski, J.B. McMahon, J.H. Cardellina II, and M.R. Boyd. 1996. HIV-inhibitory gallotannins from Lepidobotrys staudtii. Nat. Prod. Lett. 8:133-136.

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