DISCOVERIES

GENTRYMINE B

Source Plant

The Gentrymines were isolated from a sample of Ancistrocladus korupensis D. W. Thomas & Gereau (Ancistrocladaceae), a newly described species of liana originally collected in the region of Korup National Park in Cameroon in 1987 (Thomas 6889). They are named in honor of the late Alwyn H. Gentry, one of the leading authorities in tropical botany, who died in an airplane crash in western Ecuador on August 3, 1993.

Chemical Structure

 Gentrymine B 

Activity

Gentrymine B is the first quaternary naphthyl tetrahydroisoquinoline alkaloid found in the families Ancistrocladaceae and Dioncophyllaceae.

References

Hallock, Y.F., J.H. Cardellina II, T. Kornek, K.P. Gulden, G. Bringmann, and M.R. Boyd. 1995. Gentrymine B, the first quaternary isoquinoline alkaloid from Ancistrocladus korupensis. Tetrahedron Lett. 36:4753-4756.

Thomas, D.W. and R.E. Gereau. 1993. Ancistrocladus korupensis (Ancistrocladaceae): a new species of liana from Cameroon. Novon 3:494-498.

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