DISCOVERIES

GUTTIFERONE A

Source Plant

Guttiferone A is found in both Garcinia livingstonei T. Anders. (Gereau and Lovett 2678), originally collected in the Mufindi District of Iringa Region of Tanzania in December of 1988, and Symphonia globulifera L.f., originally collected in the Ndakan Gorilla Study Area of the Central African Republic in March 1988 (Fay 8278). Both species are members of the Clusiaceae.

Chemical Structure

 Guttiferone A 

Activity

The Guttiferones are polyisoprenylated benzophenone derivatives that inhibit the cytopathic effects of in vitro HIV infection.

Reference

Gustafson, K.R., J.W. Blunt, M.H.G. Munro, R.W. Fuller, T.C. McKee, J.H. Cardellina II, J.B. McMahon, G.M. Cragg, and M.R. Boyd. 1992. The Guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia, and Clusia rosea. Tetrahedron 48:10093-10102.

 © 1995- Missouri Botanical Garden, All Rights Reserved
 P.O. Box 299, St. Louis, MO 63166-0299
 314-577-5100