DISCOVERIES

GUTTIFERONE E

Source Plant

Guttiferone E was isolated from a sample of Garcinia ovalifolia Oliv. (Clusiaceae) collected in the Ndakan Gorilla Study Area of the Central African Republic in March of 1988 (Fay 8287).

Chemical Structure

 Guttiferone E 

Activity

The Guttiferones are polyisoprenylated benzophenone derivatives that inhibit the cytopathic effects of in vitro HIV infection.

Reference

Gustafson, K.R., J.W. Blunt, M.H.G. Munro, R.W. Fuller, T.C. McKee, J.H. Cardellina II, J.B. McMahon, G.M. Cragg, and M.R. Boyd. 1992. The Guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia, and Clusia rosea. Tetrahedron 48:10093-10102.

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